• Training Course:

ON - LINE coupling of chromatographic separation techniques and NMR SPECTROSCOPY

In Cooperation with BRUKER ANALYTISCHE MESSTECHNIK , KARLSRUHE

• Solid-State NMR Seminar in Oberjoch

Directors :
Priv.-Doz. Dr. Klaus Albert
Institut für Organische Chemie der Universität Tübingen
email: klaus.albert@uni-tuebingen.de(klaus.albert@uni-tuebingen.de)

Prof. Dr. Ernst Bayer
Institut für Organische Chemie der Universität Tübingen

Date :
October 07. - 09., 1996
monday, 09.00 to wednesday, 17.00 hours

Place :
Hörsaalzentrum MORGENSTELLE; Hörsaal N1
Institut für Organische Chemie,
Auf der Morgenstelle 18,
D-72076 Tübingen

Course costs :
DM 980,--; (including documentation, coffee breaks)

Minimum / Maximum Attendance 8 / 16

Information / registration:
WiT - Wissenstransfer,
Universitätsbund Tübingen
Wilhelmstraße 5,
D-72074 Tübingen
Tel.: 07071/29-6439;
Fax: 07071/29-5990;
e-mail: wit@uni-tuebingen.de(wit@uni-tuebingen.de)

Aim of the training course:
Participants will learn the theoretical basis of on-line separation science-NMR coupling techniques with respect to chromatographic and spectroscopic background knowledge.

Practical on-line separation and identification examples will demonstrate the enormous power of this hyphenated technique. Thus participants will be enabled to solve problems by themselves.

Time course:
Twelve lectures will deal with the theoretical background of both the separation science and the NMR spectroscopy. Special attention will be given to problems encountered with on-line separation-NMR coupling effecting chromatographic separation as well as NMR acquisition conditions. Practical examples will demonstrate how to deal with structure elucidation of unknown compounds.

The basic theoretical background of NMR spectroscopy, separation science and on-line coupling is carefully outlined in the manuscript of the training course.

Practical problems encountered with on-line separation-NMR detection experiments will be discussed during the practical exercises (12 hours) on a BRUKER ARX 400 and a BRUKER AMX 600. Participants are encouraged to bring "public domain" problems into the training course and to solve these problems therein. The NMR staff of the NMR department of the Institute of Organic Chemistry will assist in interpretation of NMR spectra.

Topics:

• investigation methods of Nuclear Magnetic Resonance - an overview
• chromatographic separation techniques - an overview
• theory and applications of continuous-flow NMR-spectroscopy
• solvent suppression techniques in LC-NMR studies
• handling and processing of LC-NMR data
• theory and applications of two-dimensional assignment techniques (H, H COSY, H, C COSY, NOESY, ROESY, TOCSY) and inverse experiments
• stationary phases for reversed phase and size exclusion chromatography
• separation and NMR acquisition requirements for successful on-line coupling experiments
• pathways for structure elucidation of unknown compounds
• practical HPLC-NMR and GPC-NMR on-line coupling experiments in the fields of monomers, polymers, body fluids and drugs

Solid-State NMR Seminar in Oberjoch

13.10.96 - 17.10.96

For more information send an email to: matthias.pursch@uni-tuebingen.de(matthias.pursch@uni-tuebingen.de)